Senior Scientist, in Vitro Safety

hace 2 semanas

Barcelona, España AstraZeneca A tiempo completo

**Senior Scientist, In Vitro Safety & Mechanistic Pharmacology**

**Barcelona, Spain | Gothenburg Sweden | Gaithersburg US**

**Competitive salary and benefits**

At AstraZeneca, we turn ideas into life changing medicines. Working here means being results oriented, thinking big and working together to make the impossible a reality

**Make a more meaningful contribution. Impact patients’ lives every day**

Make a meaningful impact in your career, with greater ownership and accountability to make a contribution. And in returnwe’re looking for people driven by making a difference to patients’ and society, dedicated to doing the right thing

**About the team**

**Clinical Pharmacology & Safety Sciences (CPSS) **is a multi-faceted department which underpins AstraZeneca’s Biopharmaceutical and Oncology Portfolio from target selection through to Life-cycle management.

The **Regulatory Toxicology and Safety Pharmacology** team sits within CPSS and plays a central role in progressing a rich and diverse pipeline comprising many different modalities across all of our therapeutic areas. We work collaboratively to deliver safety science from early discovery through clinical development, with emphasis on the science and studies required to enable the clinical development of new medicines.

We are currently looking to recruit a dedicated **in vitro pharmacologist** to join the Safety & Mechanistic Pharmacology team, to help deliver our growing portfolio.

**The role**

Working closely with drug safety specialists and project safety pharmacologists, you’ll be key in helping to influence drug design early in drug discovery. You’ll aid the selection of safer molecules and contribute towards the development of mitigation plans for the safety risks identified.

This role is primarily desk-based and would suit a highly motivated, capable scientist who has a desire to join a vibrant group of like-minded experts in their field and to collaborate with global AstraZeneca scientists to support drug safety assessment - a critical component of the drug discovery and development process.

**What you’ll do**
- Generate in vitro pharmacological profiling data
- Identifying off-target risks of concern, interpreting undesirable off target pharmacological interactions and translating in vitro activity at specific targets to pre-clinical and clinical adverse events to contextualise the potential safety related risks
- Interpreting in vitro off-target pharmacological profiling data to influence project decision-making and compound selection
- Designing and implementing bespoke in vitro mechanistic work-plans to address project specific drug safety/toxicity questions and increase our understanding of the translation of in vitro to in vivo
- Maintaining an awareness of current developments in literature and contributing towards the continuous improvement of AstraZeneca’s off-target profiling strategy
- Presenting scientific data alongside interpreting and relaying this data to project teams, departmental or functional meetings; and externally via poster and oral conference presentations and authorship on peer-reviewed publications.

**Essential Criteria**
- A PhD (or equivalent) in a relevant scientific specialism with a strong grounding in pharmacology (e.g. pharmacology, biology, biochemistry, toxicology, physiology) with an exceptional track-record in driving innovative science, preferably in the pharmaceutical or biotechnology industry
- Strong technical experience of in vitro pharmacological or biochemical assay development and screening (e.g. radioligand binding, enzyme activity and functional cell-based systems) as applied to a range of biological target classes
- Experience of integrative pharmacology/physiology in the drug discovery and development context
- Excellent problem-solving skills, focus on delivery and outstanding communication skills
- A true collaborator, you will be team-centric, you’ll demonstrate highly effective networking skills and will be practised in collaborating across interfaces of scientific specialism, culture, and expertise.

**Desirable Criteria**
- A practical understanding of broad profiling technologies, such as proteomics would be beneficial

**So far as is possible, we are looking at holding initial telephone interviews, week commencing, 20th February 2023 and progress to final panel interviews to be held virtually via MS Teams, from 1st to 3rd March 2023.**

**Why AstraZeneca?**

**Make a more meaningful impact to patients’ lives around the globe.**

With science at its heart, this is where breakthroughs born in the lab become transformative medicines - for the world’s most complex diseases. Answer unmet medical needs by pioneering the next wave of science, focusing on outcomes and shaping the patient ecosystem.

**We’re dedicated to being a Great Place to Work**

Where you are empowered to push the boundaries of science and unleash your entrepreneurial spirit. There’s no b

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