Diagnostic Science Manager

hace 3 días

Barcelona, España AstraZeneca A tiempo completo

AstraZeneca delivers companion and complementary diagnostic assays that match medicines to those patients who are most likely to benefit from them. This approach, known as Precision Medicine, is based on those individual characteristics that make some patients respond to treatment better than others. We use this knowledge to develop diagnostic tests that doctors can use to help prescribe the best treatment for each patient.

As a Manager, Diagnostics Science, you will use your knowledge of oncology diagnostic technologies and approaches (e.g. Next Generation Sequencing (NGS), Immunohistochemistry (IHC), digital pathology) to provide scientific and technical expertise to deliver innovative diagnostic approaches to AstraZeneca’s clinical portfolio, through strategic partnerships with leading diagnostic companies and laboratory-based science delivery.

**Accountabilities**

The role holder will be accountable for:

- Being responsible for the delivery of diagnostic science and innovation projects, through close collaboration with the cross-functional teams
- Building and maintaining a knowledge of current and new technologies in diagnostics, with a particular focus on oncology, and seeing opportunities for innovation and internal/external collaborations
- Developing innovative diagnostic science proposals across core therapeutic areas
- Evaluating the performance of novel diagnostics through delivery of diagnostic feasibility studies and laboratory-based science to timelines and budget
- Providing scientific and strategic feedback into precision medicine approaches for diagnostic and drug product teams
- Ensuring that all activities are delivered demonstrating behaviours and values aligned to AstraZeneca Code of Conduct and supporting policies, standards and procedures, including compliant management of Budget, Safety, Health and Environment

**Essential Skills/Experience**
- Record of delivery in a scientific capability, including peer-reviewed publications
- Expertise with one or more of these technologies (for example, but not limited to: NGS, PCR, IHC, digital pathology & imaging)
- Excellent knowledge of current technology trends in oncology diagnostics and precision medicine
- Experience of working with external partners or collaborators (ideally academic investigators and diagnostic companies)
- Ability to communicate with cross-functional stakeholders for project updates through oral presentations and progress reports

**Desirable Skills/Experience**
- Experience of leading projects within a diagnostic or drug development organisation
- An understanding of drug and companion diagnostic assay co-development and commercialisation and experience working in early and/or late phase projects
- Demonstrable experience of analytical diagnostic assay validation, use in a clinical testing setting and/or delivery of regulatory submission
- Good computational and data analysis skills enabling automated/semi-automated analysis of large datasets (e.g. using software and programming languages such as R, Python, knime or equivalent)
- Knowledge of requirements related to handling of Human Biological Samples

When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life-changing medicines. In-person working gives us the platform we need to connect, work at pace and challenge perceptions. That's why we work, on average, a minimum of three days per week from the office. But that doesn't mean we're not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world.

Work with diverse minds, all united by a shared passion to learn, grow and discover. Join our unrivalled scientific community that fuses academia and industry. We work seamlessly and inclusively together. Playing to each of our strengths, celebrating successes and learning from the best. Embrace the exposure to build a meaningful career. Internally we are a diverse community with female leaders in 45% of senior roles. Externally we have 475 pre-clinical collaborations in over 26 countries worldwide. In addition, we have established a collaborative research initiative that brings together seven of the world's foremost oncology medical centres, to expedite research in some of the hardest-to-treat cancers.

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