Senior Scientist
hace 2 semanas
**Date**:10-Feb-2023
**Location**: SFEL - R&D SANT FELIU DE LLOBR, ES, ES - Spain
**Company**:Almirall
**Mission**:
The cellular immunologist will design and execute plans to identify and validate new therapeutic targets of interest in cell models that are highly relevant to autoimmune or inflammatory skin diseases. In addition, he/she will be responsible for the design and development of in vitro assays to characterize the function and mechanism of action of small molecule/biologics/new modalities and drive understanding of their therapeutic potential.
We are looking for an immunologist who is passionate about using her/his deep understanding of autoimmune and inflammatory disease to make impactful contributions to clinical drug development, from exploratory research to preclinical development with the final goal of bringing new therapeutic options to dermatology patients.
**Tasks and Responsibilities**:
- Identify, evaluate, and probe emerging methods for immune cells isolation, culture, differentiation, and activation.
- Develop physiologically relevant cell models of autoimmune and inflammatory skin diseases, that accurately represent human tissue microenvironment and are predictive of clinical outcome.
- Characterize disease-relevant cell models and samples using state-of-the art methodologies including omics, multi-parameter flow cytometry, imaging, proliferation, and immunoassays.
- Design, execute, interpret, and improve in vitro assays in the cellular immunology field that can encompass assays reporting on cellular signalling, protein/mRNA quantification, post-translational modifications, cellular differentiation, proliferation, receptor binding.
- Collaborate with cross-functional teams to generate and probe new therapeutic hypothesis and modalities for skin inflammatory diseases, including orphan diseases.
- Drive and coordinate collaborative research projects that involve internal and external partners.
- Present research plans, experimental results, and data analysis at cross-functional meetings
**Education**:
PhD, or MSc with 3+ years of experience, in Cell Immunology/Molecular Immunology
**Skills**:
- A strong experimental and theoretical background in T, B, NK and myeloid cell immunology and experience studying gene regulation and function in primary cells. Experience with CD8 and/or Treg biology would be a plus.
- Proficiency in cellular assays such as flow cytometry, ELISA, HTRF, qPCR, WB. Experience with functional immunology assays (e.g. MLRs) and imaging techniques would be desirable.
- Experience with basic molecular biology techniques (cloning, transfections..). Experience with gene editing (CRISPR) would be a plus.
- Experience working with ex-vivo human skin biopsies would be a plus.
- Interest in new modalities such as bispecific antibodies, Targeted Protein Degradation or gene therapy would be a plus.
- Track record of continual growth, curiosity, and drive to learn.
- Ability and enthusiasm to propose innovative out-of-the-box solutions, critically evaluate data, generate testable hypotheses, and solve challenging interdisciplinary problems.
- Team player with ability to communicate effectively across several scientific disciplines
- Proficiency in written and spoken English
**Values**:
- Caring
- Dedicated
- Dynamic
- Expert
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