Predoctoral Researcher

hace 2 semanas

Madrid, España Fundació Hospital Universitari Vall D'Hebron- Institut De Recerca A tiempo completo

Organisation/Company Fundació Hospital Universitari Vall d'Hebron- Institut de recerca

Department: Research Department

Research Field: Biological sciences

Researcher Profile: First Stage Researcher (R1)

Positions: Master Positions

Country: Spain

Application Deadline: 31 Dec 2024 - 23:59 (Europe/Andorra)

Type of Contract: Temporary

Job Status: Full-time

Offer Starting Date: 7 Oct 2024

Is the job funded through the EU Research Framework Programme? Other EU programme

Is the Job related to staff position within a Research Infrastructure? No

Offer Description
Vall d'Hebron Research Institute (VHIR) offers a position for a Predoctoral researcher within the Laboratory of the Cardiovascular Diseases Research Group to participate in the project "Inhibition of mitochondrial sodium/calcium exchanger, NCLX, as a therapeutic strategy to reduce myocardial ischemia-reperfusion injury during myocardial infarction", recently funded by Instituto de Salud Carlos III, from Ministerio de Ciencia, Innovación y Universidades (PI23/00260).

Main responsibilities and duties:

To develop the doctoral thesis project and collaborate in other projects of the research group.

To develop their own translational research project to solve an unmet clinical issue in cardiology, including designing, performing and interpreting results from both in vivo and in vitro experiments.

To join the research team and support other research members in their projects.

To generate fruitful discussions within the group.

To present and defend results at national and international scientific meetings.

Participation in group meetings and other activities.

Degree in Health Sciences (Biology, Biomedicine, Pharmacy, Veterinary Medicine or a related discipline).

High academic marks (degree and master's) are necessary, including submission of the academic record.

Good communication skills and fluency in spoken and written English.

Strong sense of responsibility, initiative, self-motivation and social skills.

Ability to work independently.

Research stages abroad.

Accreditation for the use of animals in research.

Experience and knowledge:

Good knowledge of animal physiology, especially in the cardiovascular system.

Previous experience in molecular biology methods and research.

Good molecular biology background and experience in techniques like Western Blot, PCR, immunofluorescence, etc.

Critical thinking and the ability to analyze and evaluate information critically.

Languages: ENGLISH Level Good

Additional Information
Labour conditions:

Position: Full-time predoctoral position (40h/week) after application to a research grant.

Starting: According to conditions established by the grant holder.

Duration: 4 years.

Gross annual salary: According to conditions established by the grant holder.

Project Summary:

Background: A key role for the mitochondrial sodium/calcium exchanger, NCLX, in reactive oxygen species (ROS) production during ischemia has been recently unveiled. Preliminary results show that NCLX inhibition can also abolish ROS production during reperfusion and reduces infarction in a mouse model of stroke. We want to address whether the same mechanism operates in cardiomyocytes, and the therapeutic potential of NCLX inhibition.

Objectives: (1) To characterize the role of NCLX in ROS production during IR in cardiomyocytes; (2) to evaluate if novel NCLX inhibitors constitute a promising therapeutic approach to reduce IR injury.

Methods: We will perform a detailed molecular study of the effects of mitochondrial sodium-calcium exchange during IR, using isolated hearts, in vivo rodent and pig models of myocardial infarction, and cardiomyocytes isolated from human atrial samples.

What can we offer?

Incorporation to Vall d'Hebron Research Institute (VHIR), a public sector institution that promotes biomedical research.

A scientific environment of excellence and continuous learning.

Individual training opportunities.

23 days of holidays + 9 personal days.

Flexible Remuneration Program.

Corporate Benefits for significant discounts.

Healthy Offering for wellbeing activities.

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