Vac_71_2024_Lab Assistant Trainee

Your missionThe Josep Carreras Leukaemia Research Institute (IJC) is a nonprofit research institute based in the metropolitan area of Barcelona and dedicated to advancing our understanding about leukaemia and related disorders, in partnership with the University of Barcelona and University Autònoma of Barcelona. 
The Josep Carreras Leukemia Research Institute Can Ruti is looking for a Lab Assistant Trainee for the Cancer Metabolism group led by Dr. Lucas Pontel.
Cancer is a major global health concern and understanding its underlying mechanisms is essential for developing effective treatments. Cancer cells undergo genetic and epigenetic changes, activating oncogenes and silencing tumor suppressor genes. These malignant cells also exhibit metabolic reprogramming for obtaining energy and nutrients differently than normal cells, granting them a growth advantage. To sustain this uncontrolled growth, cancer cells depend on robust antioxidant defenses, primarily provided by abundant nucleophilic molecules such as glutathione (GSH). 
This project is focused on investigating and harnessing the functions of cellular nucleophilic metabolites, such as glutathione and cysteine, in the protection of the cancer genome and in the maintenance of the epigenome in cancer cells. Our endeavor involves the implementation of comprehensive genome-wide omics methodologies, including pooled CRISPR/screens within cellular models representative Acute Myeloid Leukemia (AML). Through this research, we aim to pioneer novel therapeutic strategies that trigger cell death in leukemic cells by precisely targeting metabolic pathways integral to defense mechanisms against detrimental metabolites. 
This contract is part of the project PID******** NB-I00 funded by MCIN/AEI/10.13039/******** / EDRF 'A way to make Europe', UE.

Main responsibilitiesEstablish and maintain cellular models relevant for the aim of the project.Apply cell biology and molecular biology techniques to characterize the cellular models.Contribute to carry out CRISPR/Cas9 genome-wide screenings.Assist in lab organization tasks like inventory tracking, reagent preparation, and supply ordering.Collect and record experimental data, ensuring meticulous record-keeping and data quality.Engage in literature reviews to stay updated on relevant advancements.Collaborate effectively with the research team, contributing to lab meetings and discussions.Seize opportunities for skill development and scientific growth. Your profileGeneral skillsCommitted scientist with a competitive scientific record and experience in biology, biomedicine or related discipline.A high level of motivation and interest in biomedical research.Good communication skills.Fluent in EnglishTechnical skillsDegree in Biology or Biochemistry (or related field).MSc in Biology or Biochemistry (or related field).A high-level of motivation and interest.Experience in immunology, molecular biology, biochemistry and/or cellular biology.Additional work and lab expertise on mouse models will be positively evaluated.High level of collaborative and communicative skills.High level of English speaking and writing skills (required). Spanish (helpful). Why us?6 months trainee contract, with possibility of a 6-month extension.Start date: October/November 2024.A salary that with commensurate your qualifications.The stimulating environment of the IJC and its scientific network. DeadlinePlease submit your application by 30th September 2024 For further information please contact ******** About usWhat makes us different? The mission of the Josep Carreras Institute is to conduct research and drive innovation in the epidemiological, preventive, clinical, translational, and basic aspects of cancer, with a special emphasis on leukaemia and other hematologic malignancies, with the final aim of finding a cure for these diseases. The IJC's vision is to be a world-class reference and excellent research multicampus that contributes to the improvement of results, and the cure of patients affected by leukemia and other malignant hemopathies, through innovation, sustainability, social responsibility, talent, and professional experience. HR Excellence In 2019, IJC was honored with the "Human Resources Excellence in Research Award" by the European Commission, recognizing the alignment of our human resources policies with the European Charter for Researchers and Code of Conduct for the Recruitment of Researchers. The Human Resources Strategy for Researchers (HRS4R) guides research centers of excellence in implementing and upholding these standards within their policies, emphasizing training, professional development, and mobility opportunities. The IJC's commitment to these values and principles strengthens our internal policies and ensures that our members have the optimal conditions and environment for their professional development. The IJC is an equal opportunity employer. We evaluate qualified applicants without regard to race, color, religion, sex, national origin, disability, or other legally protected characteristics.