Researcher R2
hace 2 semanas
Organisation/Company Principe Felipe Research Center Research Field Biological sciences » Biology Chemistry » Biochemistry Biological sciences » Other Researcher Profile Recognised Researcher (R2) Positions Postdoc Positions Country Spain Application Deadline 20 Dec 2024 - 12:00 (Europe/Madrid) Type of Contract Temporary Job Status Full-time Hours Per Week 37.5 Offer Starting Date 15 Jan 2025 Is the job funded through the EU Research Framework Programme? Not funded by a EU programme Is the Job related to staff position within a Research Infrastructure? No
Offer Description Metabolically Associated Fatty Liver Disease (MASLD) is a relatively benign condition where excess fat accumulates in the liver of individuals who consume little or no alcohol. MASH (metabolic dysfunction-associated steatohepatitis) is a more advanced and potentially severe form of MASLD. In this condition, not only does the liver accumulate fat, but there is also inflammation and liver cell damage (hepatitis). The importance of MASLD and MASH problems cannot be overstated. MASH affects around 25% of the population and is strongly linked to metabolic syndrome, obesity, diabetes, dyslipidaemia, and hypertension. It is a risk factor for heart failure and liver pathologies such as cirrhosis and hepatocellular carcinoma (HCC). The prevalence of MASH is increasing, exacerbated by factors like obesity, ageing populations, and even its emergence in children and adolescents. Thus, identifying factors that facilitate the transition from MASLD to MASH might help to prevent the torpid evolution of the natural history of the disease.
We are seeking a highly motivated Senior Postdoctoral fellow to join Professor Antonio Vidal-Puig's (I-81) at Centro de Investigacion Principe Felipe. This role will include two main tasks: a) lab management and b) contribution to our research that focuses onidentifying factors that facilitate the transition from MASLD to MASH that might help to prevent the torpid evolution of the natural history of the disease.
Key Responsibilities:
Oversee the daily operations of the laboratory.
Continuously monitor the development, execution, and expenses of the project, assisting institutional project management services, the project leader, and the work team.
Contribute to the supervision of students, predoctoral and junior post-docs
Assist in preparing project justification reports.
Contribute to disseminating project work and assist in project dissemination and communication activities.
Lead one or more research projects, managing all aspects from experimental design to data generation, analysis, interpretation, and publication.
Conducted in vitro cell work and vivo phenotypic characterization of murine models and performed lab-based molecular research.
Present research findings internally and at national and international conferences, aiming for publication in high-impact journals.
Basic requirements of the position:
Strong background in laboratory management, excellent organizational skills, and the ability to lead and motivate a team of laboratory technicians and scientists
Proficiency in standard molecular and cell biology techniques including, but not limited to, Mammalian cell culture, cell sorting, ex vivo and in vivo imaging (e.g. confocal, multimodal nonlinear optical microscopy, SIM, etc).
Strong experience in vivo studies and metabolic phenotyping
Candidates with additional relevant skills, such as expertise in either bulk or single-cell RNAseq/proteomics analysis
Strong IT, data management and organizational skills.
Ability to work independently and as part of a team.
Effective communication skills with a scientific ethos, passion for problem-solving, and creative thinking.
License to work with mice
Excellent English written and oral skills
Experience required:
PhD or equivalent degree in Biology, Biochemistry, or a related discipline.
Minimum of 3 years postdoctoral experience
Experience in cardiometabolic research, especially regarding liver biology and MASLD.
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