Predoctoral Researcher Position

hace 2 semanas

Barcelona, Barcelona, España Vall d'Hebron Institut de Recerca A tiempo completo
VHIR-RRHH-FOR-003_vs01_

The Vall d'Hebron Research Institute

(VHIR) is a public sector institution that

promotes and develops the research,

innovation and biosanitary teaching of the

Vall d'Hebron University Hospital. Through

the excellence of our research, we identify

problems of society and we contribute to

spread them around the world.

In April 2015, the
Vall d'Hebron

Research Institute (VHIR) obtained

the recognition of the European

Commission in
HR Excellence.
This recognition proves that VHIR

endorses the general principles of the

European Charter for Researchers and

a Code of Conduct for the Recruitment

of Researchers
(Charter & Code).

VHIR embraces Equality and

Diversity. As reflected in our values

we work toward ensuring inclusion

and equal opportunity in

recruitment, hiring, training, and

management for all staff within the

organization, regardless of gender,

civil status, family status, sexual

orientation, nationality, religion,

age, disability or race.

Predoctoral Researcher Position

Clinical Neuroimmunology Group
The Clinical Neuroimmunology Group is part of the Centre d'Esclerosi Múltiple de Catalunya (Cemcat), a reference center
for multiple sclerosis (MS) at national and international levels. The Cemcat has a multidisciplinary team with more than
70 highly experienced professionals fully dedicated to clinical care, physical and cognitive rehabilitation, teaching, and

The predoctoral researcher will work on a project entitled "New human induced pluripotent stem cell-based in vitro and in
vivo models to study astrocyte pathology and neuroprotective strategies in multiple sclerosis patients", that is currently
funded by the Instituto de Salud Carlos III.

Summary of the project:
Multiple sclerosis (MS) has traditionally been considered an autoimmune inflammatory neurological disorder in which the
primary event is an aberrant immune response against central nervous system (CNS) autoantigens in predisposed
individuals. This leads to infiltration of peripheral blood cells into the CNS and results in inflammatory demyelination and
eventually axonal damage. While this probably holds true, in the present proposal we will test the hypothesis that MS
patients may have a primary defect in astrocytes that renders these cells dysfunctional and more reactive to the
autoimmune attack, making white matter lesions less prone to remyelinate. To this aim, we will generate human induced
pluripotent stem cells from patients with primary progressive MS and relapsing-remitting MS in order to investigate human
astrocyte pathology in an inflammatory environment in vitro and in vivo, through the development of two new models

created by:
(i) exposing astrocytes in vitro to cerebrospinal fluid obtained from MS patients with high inflammatory
radiological phenotypes; (ii) transplanting human glial progenitor cells into the developing mouse CNS and inducing
experimental autoimmune encephalomyelitis. The proteomic signature of astroglial secretome will be examined in vitro,
under basal and inflammatory conditions. The genomic signature of MS human astrocytes during EAE progression will

be examined in vivo by spatial transcriptomics, to identify differentially expressed genes whose expression may be
modulated by small-molecule compounds with the potential to become future neuroprotective therapies for patients with
MS.

  • VHIR-RRHHFOR003_vs01_
The Vall d'Hebron Research Institute

(VHIR) is a public sector institution that

promotes and develops the research,

innovation and biosanitary teaching of the

Vall d'Hebron University Hospital. Through

the excellence of our research, we identify

problems of society and we contribute to

spread them around the world.

In April 2015, the
Vall d'Hebron

Research Institute (VHIR) obtained

the recognition of the European

Commission in
HR Excellence.
This recognition proves that VHIR

endorses the general principles of the

European Charter for Researchers and

a Code of Conduct for the Recruitment

of Researchers
(Charter & Code).

VHIR embraces Equality and

Diversity. As reflected in our values

we work toward ensuring inclusion

and equal opportunity in

recruitment, hiring, training, and

management for all staff within the

organization, regardless of gender,

civil status, family status, sexual

orientation, nationality, religion,

age, disability or race.
It is important to remark that the Clinical Neuroimmunology Group cares a lot about teaching, and high-quality training of
predoctoral researchers is one of the top group's priorities
_. _

JOB DESCRIPTION
**Education and qualifications:
Required
Degree in health sciences (biology, pharmacy, biochemistry, biotechnology, biomedicine, medicine, etc...).

Official Master in health sciences

High academic record

Desired:

Master in

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